To clot or not

The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.

BACKGROUND Acute coagulopathy of trauma (ACOT) has been described as a very early hypocoagulable state, but the mechanism remains controversial. One proposed mechanism is tissue hypoperfusion leading to protein C activation, with subsequent inhibition of Factors V and VIII. Variability in trauma has impeded the use of clinical data towards the elucidation of the mechanisms of ACOT, but thrombel...

Folic Acid Supplementation: to Advise or not to Advise?

Procoagulant activity on platelets adhered to collagen or plasma clot.

In a new 2-stage assay of platelet procoagulant activity (PCA), we first subjected gel-filtered platelets to adhesion on collagen (as a model of primary hemostasis) or plasma clots (as a model of preformed thrombus) for 30 minutes, and then the adherent platelets were supplemented with pooled, reptilase-treated, diluted plasma. Defibrinated plasma provided coagulation factors for assembly on pl...

to be or not to be that’s the question-3

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Approaches of Islamic Ideology to interfere or not to interfere in the area of divergence

  Introduction: The principles of the School of Natural Rights during the Age of Entitlement, i.e., the 17th and 18th centuries, regarding the centrality of human being, his freedom and self-determination, as well as the human rights recommendations and documentations designed and drafted by the international organizations during the current century and the appearance of “globalization”, the...